GABA increases the flow of chloride ions into the neurons, which reduces its ability to fire electrical signals. Traditional benzodiazepine medications increase the activity of the target receptors (GABA-A). Benzodiazepine Dosage Equivalency Calculator Prolongation of the half-life to 1.3 hours in patients with moderate hepatic impairment and 2.4 hours in severely impaired patients. The initial distribution half-life of flumazenil is 4 to 11 minutes, and the terminal half-life is 40 to 80 minutes. Very little flumazenil (<1%) is found in the urine.ĭuration of Effects: Short-Acting. Metabolism: Flumazenil’s metabolism is 99% hepatic. Other Names: Anexate, Lanexat, Mazicon, & Romazicon ![]() IUPAC Name: Ethyl 8-fluoro-5-methyl-6-oxo-4H-imidazobenzodiazepine-3-carboxylate Unlike flumazenil, bretazenil maintains the classic benzodiazepine effects.Īpproved by the FDA in 1991, flumazenil is only commercially available as an injectable drug. ![]() Structurally, flumazenil is classified as a 1,4-imidazobenzodiazepine closely related to another benzodiazepine derivative called bretazenil. For example, rather than reducing anxiety-like other benzodiazepines, flumazenil induces it. Flumazenil - commercially available as Anexate, Lanexat, Mazicon, and Romazicon - is a benzodiazepine receptor antidote used for treating overdoses on other members of the benzodiazepine family.įlumazenil has the opposite effects to most benzos.
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